HPAPI – Highly Potent API

Our service for HPAPIs ranges from Drug Substance to Particle Engineering.

HPAPI – Highly Potent API

Many of NCE are considered potent compounds, meaning occupational exposure limits (OEL) <10Ìýµg/m3, which requires special handling conditions. ËÄÉ«AV has invested in its facilities in Loures, Cork and New Jersey to provide the necessary containment, defined individual protection equipment and also developed working practices to safely handle these compounds. Ìý

Our service for HPAPIs covers both Drug Substance and Particle Engineering for compounds. Our multipurpose facilities can support Drug Substance services with an OEL down to 1 µg/m3.

In the case of spray drying services ËÄÉ«AV can handle compounds with an OEL down to 0.03 µg/m3.

This combination is unique in the industry and offers our customers the ability synthesize an HPAPI and then convert seamlessly to a spray dried dispersion all on the same site.

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Also in Drug Substance Capabilities

Chromatography

ËÄÉ«AV has expanded its purification technologies to include chromatography to support development from lab to commercial scale.

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Corticosteroids

Corticosteroids are produced in two dedicated buildings on the Loures site, which are equipped with vessels ranging from 50L up to 4000L.

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Cryogenics

ËÄÉ«AV has experience in carrying out reactions at low temperatures.

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Hydrogenations

ËÄÉ«AV has vast experience in developing hydrogenation processes using both heterogeneous and homogeneous catalysis.

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Membrane Technology

ËÄÉ«AV has a wide range of membrane capabilities at its disposal including nanofiltration and ultrafiltration.

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