Knowledge Center
Patent / Jan 01, 1976
Sulfate and phosphate 21-esters of corticosteroids
Source:
US 3773803
Betametasone (I) 21-phosphate (II) was prepd. in 96.7% yield by refluxing III (R = I) in 40 ml acetone with 1.2 g H3PO4 and 5.8 ml Et3N for 3.5 hr. Salts of I 21-sulfate and II with PhCH2NHCH2CH2NHCH2Ph also were prepd.
Also in the Knowledge Center
/ Nov 18, 2020
Coupling Reaction Kinetics, Calorimetry and Mixing Studies for Successful Scale-up of Exothermic Reactions
Read more
Scientific Article
/ Nov 16, 2020
Modelling Amorphous Solid Dispersions: The Role of Supersaturation, Nucleation and Crystal Growth
Read more
Scientific Article
/ Nov 16, 2020
Liquid-Liquid Extractions in API Manufacturing Processes: Is Continuous the Way to Go?
Read more
Scientific Article