Knowledge Center
Patent / Jan 01, 1976
Sulfate and phosphate 21-esters of corticosteroids
Source:
US 3773803
Betametasone (I) 21-phosphate (II) was prepd. in 96.7% yield by refluxing III (R = I) in 40 ml acetone with 1.2 g H3PO4 and 5.8 ml Et3N for 3.5 hr. Salts of I 21-sulfate and II with PhCH2NHCH2CH2NHCH2Ph also were prepd.
Also in the Knowledge Center
/ Oct 18, 2021
Spray-Dried Composite Formulation Containing DSPC for Lung Sustained Release
Read more
Scientific Article
/ Oct 17, 2021
Understanding Dry Powder Inhalers Formulations: Role of Surface Polarity of lactose mixtures
Read more
Scientific Article
Scientific Article