Knowledge Center

Patent / Jan 01, 1976

Alkali methal polymetaphate complexes of doxycycline

Authors:
  • Ivan Villax
Source:
GB 1463726

Alkali metal polymetaphosphate complexes of doxycycline (I) were prepd. to increase I blood levels and counteract pharmacol. disadvantages due to chelation of tetracyclines. Thus, metaphosphoric acid in CHCl3 and MeOH was treated with I to give a soln. which was treated with NaOH in MeOH. After washup I polyphosphate mono-Na complex (II) [56648-96-5], m. 184-8.degree., was obtained. Administration of II gave an av. overall increase of nearly 50% serum levels compared to I hyclate.

Also in the Knowledge Center

Related Content

Formulation

We develop inhalation & nasal products with our partners following Quality by Design principles to reach optimal product performance through robust processes.

Page
Read more

Drug Substance Technologies

We constantly innovate to find better, more efficient ways of doing things.

Page
Read more

Membrane Technology

ËÄÉ«AV has a wide range of membrane capabilities at its disposal including nanofiltration and ultrafiltration.

Page
Read more