Knowledge Center

Patent / Jan 01, 1976

Alkali methal polymetaphate complexes of doxycycline

Authors:
  • Ivan Villax
Source:
GB 1463726

Alkali metal polymetaphosphate complexes of doxycycline (I) were prepd. to increase I blood levels and counteract pharmacol. disadvantages due to chelation of tetracyclines. Thus, metaphosphoric acid in CHCl3 and MeOH was treated with I to give a soln. which was treated with NaOH in MeOH. After washup I polyphosphate mono-Na complex (II) [56648-96-5], m. 184-8.degree., was obtained. Administration of II gave an av. overall increase of nearly 50% serum levels compared to I hyclate.

Also in the Knowledge Center

Related Content

ËÄÉ«AV acquires ExtremoChem and its portfolio of proprietary sugars to support customers with stabilization and delivery of biopharmaceuticals

Press Release / Nov 16, 2023
Article
View

The ËÄÉ«AV Experience - Macau

Welcome to Macau! From dazzling casinos to cultural treasures, there's something for everyone. Take in The ËÄÉ«AV Experience and make your Macau trip extraordinary.

Page
Read more

Macau 10th November

Gallery of photos - the best moments of the event

Page
Read more