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Article / Apr 03, 2020
Chalcones: Retrospective synthetic approaches and mechanistic aspects of a privileged scaffold
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Current Pharmaceutical Design, April 3, 2020
This review summarizes the synthetic methodologies used in the last 25 years in the synthesis of chalcones, which are a class of flavonoids having a 1,​3-​diphenyl-​2-​propene-​1-​one backbone.ÌýThese compounds are considered a hot topic in the field of medicinal chemistry, due to their pharmacological activity and because they are important precursors in the synthesis of heterocyclic compounds with therapeutic applications such as: flavones, flavanones, isoxazolines, benzothiazepines, pyrimidines and pyrazolines derivatives.
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