Inhalation grade particles
ËÄÉ«AV is a global expert in particle engineering, an essential technology when developing inhalation drug products.
Inhalation grade particle generation strategies
Within inhalation drug development services, ËÄÉ«AV focuses on the development ofÌýenabling particle engineering solutions for inhalation drug development, while maintaining tight control over conventional development techniques.
ËÄÉ«AV has developed its own toolkit to address the requirements of a new generation of inhalation grade particles, including bottom-up approaches such as controlled microcrystallization and top-down approaches, such as air jet milling, spray drying and wet polishing.
| Ìý |
Bottom-up approach Controlled crystallization |
Top-down approach Air jet milling Spray drying Wet polishing |
|---|---|---|
| Strengths | •ÌýTarget PS in a single step | •ÌýControl over PS and distribution •ÌýTailoring morphology and surface properties •ÌýScalable approaches available |
| Limitations | •ÌýProcess and scale-up complexity •ÌýWide PS distribution, agglomeration •ÌýLimited morphology tuning |
•ÌýRequires isolation step for wet methods •ÌýChallenges for thermolabile molecules |
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Scale-up & QbD approaches for spray-dried inhalation formulations
describe the strong position of inhalable products in preclinical and clinical pipelines.
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