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A topical formulation contg. a tetracycline is provided, comprising two sep. parts: (i) a first part comprising a tetracycline solid form suspended a first vehicle; and (ii) a second part comprising a second vehicle which the tetracycline is sol. Preferably the tetracycline is cryst. minocycline base. Suitably, a neutral vehicle is used for the first part of the formulation. The two parts of the formulation may be packaged sep. containers and are preferably topically applied therefrom simultaneously.