Knowledge Center

Patent / Jan 01, 1976

Sulfate and phosphate 21-esters of corticosteroids

Authors:
  • Ivan Villax
Source:
US 3773803

Betametasone (I) 21-phosphate (II) was prepd. in 96.7% yield by refluxing III (R = I) in 40 ml acetone with 1.2 g H3PO4 and 5.8 ml Et3N for 3.5 hr. Salts of I 21-sulfate and II with PhCH2NHCH2CH2NHCH2Ph also were prepd.

Also in the Knowledge Center

Related Content

Technologies

We offer a number of innovative particle engineering technologies, at all scales, to address recent challenges in drug delivery.

Page
Read more

·¡±è¾±»å±ð±ôâ„¢

·¡±è¾±»å±ð±ôâ„¢ is an innovative technology with the ability to deliver sustained-release pharmaceuticals via surface erosion resulting in the ability to precisely tune pharmacokinetics to meet the target indication needs.

Page
Read more

60 Years

In 2019, ËÄÉ«AV celebrates its 60th Anniversary.

Page
Read more