Knowledge Center

Patent / Jan 01, 1976

Sulfate and phosphate 21-esters of corticosteroids

Authors:
  • Ivan Villax
Source:
US 3773803

Betametasone (I) 21-phosphate (II) was prepd. in 96.7% yield by refluxing III (R = I) in 40 ml acetone with 1.2 g H3PO4 and 5.8 ml Et3N for 3.5 hr. Salts of I 21-sulfate and II with PhCH2NHCH2CH2NHCH2Ph also were prepd.

Also in the Knowledge Center

Related Content

History of ËÄÉ«AV

ËÄÉ«AV was established in Portugal in 1959 by Ivan Villax with his wife, Diane Villax, and two other Hungarian refugees: Nicholas de Horthy and Andrew Onody, thus forming the name HOVIONE.

Page
Read more

The ËÄÉ«AV Experience - Cork

Welcome to Cork! Explore the city’s hidden gems and breathtaking scenery with us! Indulge in the ËÄÉ«AV Experience and immerse yourself in Irish culture.

Page
Read more

Speak Up!

An Ethics Line to enable team members to Speak Up!

Page
Read more