Knowledge Center

Patent / Aug 06, 2015

A process for control of particle size distribution of active pharmaceutical ingredients

Authors:
  • Eunice Costa
  • Marcio Temtem
  • Luis Sobral
  • Constanca Cacela
  • Peter Villax
Source:
WO 2015114320

A new scalable process to control the particle size and the particle size distribution in active pharmaceutical ingredients (API)​, comprises 5 steps: (i) a suspension prepn. in a mixt. of solvents in which the API and​/or excipient is partially sol. in one of the solvents; (ii) particle size redn. of the suspension; (iii) aging; (iv)​stopping the aging by solvent removal; and (v) optionally, a step of isolating the processed ingredients in the form of powder.

Also in the Knowledge Center

Related Content

Inhalation grade particles

ËÄÉ«AV is a global expert in particle engineering, an essential technology when developing inhalation drug products.

Page
Read more

Drug Product Development

Leveraging our expertise particle engineering, ËÄÉ«AV can now develop oral dosage forms and inhaled dosages forms to offer dependable solutions for complex drug products.

Page
Read more

Our Policies

Our Policies (Quality, HSEE, Human Resources, Innovation & Entrepreneurship) communicate and document our values.

Page
Read more