Knowledge Center

Patent / Jan 01, 2011

Method for monofluoromethylation of organic substrates to prepare biologically active organic compounds

Authors:
  • Emilia Leitao
Source:
WO 2011151624

A process for the prepn. of monofluoromethylated org. biol. active compds. using monofluoromethylated reagents was disclosed. Thus, fluticasone propionate and fluticasone furoate I [R = CH2Me, 2-furanyl, resp.] were prepd. using S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulfonium tetrafluoroborate as monofluoromethylating reagent instead of bromofluoromethane.

Also in the Knowledge Center

Related Content

Continuous Tableting for Drug Product

ËÄÉ«AV´s pragmatic approach to bridging science with manufacturing is now being leveraged for continuous tableting and it is the key to ultimately providing high quality medicines and the success of your drug product.

Page
Read more

OWN it! Training and Development Needs FY24

Take an active role in your personal development. Follow the new process to identify, plan and own your training and development needs for FY24.

Page
Read more

Devices

ËÄÉ«AV offers simple, patented and globally competitive dry powder inhalers – Disposable, Capsule, Blister and Large Dose DPIs – which are available for fully integrated turn-key development with formulation and for licensing.

Page
Read more