Knowledge Center

Patent / Jan 01, 1976

Alkali methal polymetaphate complexes of doxycycline

Authors:
  • Ivan Villax
Source:
GB 1463726

Alkali metal polymetaphosphate complexes of doxycycline (I) were prepd. to increase I blood levels and counteract pharmacol. disadvantages due to chelation of tetracyclines. Thus, metaphosphoric acid in CHCl3 and MeOH was treated with I to give a soln. which was treated with NaOH in MeOH. After washup I polyphosphate mono-Na complex (II) [56648-96-5], m. 184-8.degree., was obtained. Administration of II gave an av. overall increase of nearly 50% serum levels compared to I hyclate.

Also in the Knowledge Center

Related Content

Exclusive partnerships

ËÄÉ«AV has experience of developing and supplying off-patent APIs on an exclusive basis.

Page
Read more

Spray congealing

Spray congealing, also known as spray cooling, is a solvent free process that transforms a melt into well defined spherical particles.

Page
Read more

Interview to the 3 Generations of the Villax Family

Summary of the interview to the Villax family at the B Corp Summer Summit 2017

Page
Read more