Knowledge Center

Patent / Jan 01, 1976

Alkali methal polymetaphate complexes of doxycycline

Authors:
  • Ivan Villax
Source:
GB 1463726

Alkali metal polymetaphosphate complexes of doxycycline (I) were prepd. to increase I blood levels and counteract pharmacol. disadvantages due to chelation of tetracyclines. Thus, metaphosphoric acid in CHCl3 and MeOH was treated with I to give a soln. which was treated with NaOH in MeOH. After washup I polyphosphate mono-Na complex (II) [56648-96-5], m. 184-8.degree., was obtained. Administration of II gave an av. overall increase of nearly 50% serum levels compared to I hyclate.

Also in the Knowledge Center

Related Content

Corticosteroids

Corticosteroids are produced in two dedicated buildings on the Loures site, which are equipped with vessels ranging from 50L up to 4000L.

Page
Read more

HPAPI – Highly Potent API

Our service for HPAPIs ranges from Drug Substance to Particle Engineering.

Page
Read more

Nanoparticles

At ËÄÉ«AV we have both top-down and bottom-up technologies to produce pharmaceutical nanoparticles for oral delivery.

Page
Read more