Knowledge Center
Patent / Jan 01, 1972
9-Fluoro-16.beta.-methyl steroids
Source:
US 3792046
The title compds. (I) were prepd. from pregnatriene (II) by treatment with MeCONHBr and aq. HClO4 to give the 9.alpha.-bromo-11.beta.-hydroxy deriv., treatment with NaOH to give the 9,11-epoxy deriv. which was treated with aq. HF to give I (R = H) which could be treated with I-MeOH in the presence of CaO to give the 21-diiodo deriv. which was treated with KOAc, giving I (R = OAc).
Also in the Knowledge Center
/ May 19, 2020
Roller Compaction scale-up made simple: an approximate analytical solution to Johanson's rolling theory
Read more
Scientific Article
/ Apr 03, 2020
Chalcones: Retrospective synthetic approaches and mechanistic aspects of a privileged scaffold
Read more
Scientific Article
Scientific Article