Knowledge Center

Patent / Jan 01, 1973

16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione and analogs

Authors:
  • Ivan Villax
Source:
GB 1397267

Pregnatrienedione I was prepd. from epoxypregnanetrione II in 7 steps. Thus, II underwent ketalization with HOCH2CH2OH, KBH4 redn., dehydration, Grignard reaction with MeMgBr, and deketalization to give pregnenedione III. III was treated with Br2-HOAc and then debrominated to I.

Also in the Knowledge Center

Related Content

Process Safety

Process safety is a blend of engineering and management skills that focuses on the prevention of events impacting safety, environmental damage and business losses.

Page
Read more

HPAPI – Highly Potent API

Our service for HPAPIs ranges from Drug Substance to Particle Engineering.

Page
Read more

Procurement

We partner, connect and align to shape supplier solutions that help ËÄÉ«AV reach its growth and objectives.

Page
Read more