Knowledge Center
Webinar - Powder rheology: make it flow & avoid surprises at downstream processing
Watch On-demand
(Restricted content)
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Speakers |
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| Maria Paisana, PhDÌý-ÌýAnalytical Scientist, R&D Analytical Development |
| SlavomÃra Doktorovová, PhD - Process Development Scientist, R&D Drug Product Development |
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The extensive use of powders in the pharmaceutical industry has generated a variety of methods to characterize powder flow properties. Not surprisingly, a number of references appear in scientific literature, attempting to correlate the various types of powder flow to manufacturing methods. The development of such a variety of testing methods was unavoidable since powder behavior is multifaceted and thus complicates the effort to effectively characterize powder flow. Methods to characterize the flowability of blends are numerous and include conventional compendial methods, or other more innovative methods of characterization of powders using powder rheometers.Ìý
This webinar will include a systematic evaluation of powder flow methods, with the goal of correlating the blend’s flowability with the physical attributes of the final dosage forms. Knowledge about the blends’ flowability in early stages of pre-formulation enables the formulator to prevent potential problems related with powder flow, such as segregation, difficult handling, unacceptable tablet weight variation and tablet defects.
Key learnings:
- To understand the added value of the different data generated by different powder flow methodologies, therefore avoiding redundancy in formulation development;
- To take decisions regarding tablet formulation backed by powder rheology data.