Knowledge Center

Poster / Apr 25, 2017

Optimization of Formulation and Process Parameters for the Manufacture of Inhalable Composite Particles by Spray-Drying

Authors:
  • Maria Palha
Source:
RDD Europe 2017

Dry powders for inhalation are typically formulated using a carrier-聽based approach. However, limitations such as poor drug delivery uniformity are frequently observed. Moreover,聽since combination therapies are gaining momentum for the treatment of respiratory diseases, the addition of a second API further increases the complexity of the formulation. In order to overcome these challenges,聽the engineering of carrier free composite particles in which the API is embedded within an excipient matrix is a suitable alternative,聽with spray drying (SD)聽being the preferred particle engineering technology.