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Poster / Nov 13, 2016

Aerodynamic Performance of DPIs versus Process Efficiency

Authors:
  • Filipa Maia
  • Maria Palha
  • Isabel Lopes
  • Filipe Neves
Source:
AAPS 2016

Dry powder inhalers target optimal performance, but should also consider the robustness of the downstream processes. Blend compositions which improve Fine Particle Fraction (FPF5μ³¾/·¡¶Ù) hinder process yield (rejection rate, RR) and device performance (emitted dose, ED). This work establishes relationships between blend rheology, product performance and downstream process efficiency and sets a Design Space which integrates different trade-offs between Product and Process optimization.

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