Knowledge Center
Patent / Jan 01, 1976
Sulfate and phosphate 21-esters of corticosteroids
Source:
US 3773803
Betametasone (I) 21-phosphate (II) was prepd. in 96.7% yield by refluxing III (R = I) in 40 ml acetone with 1.2 g H3PO4 and 5.8 ml Et3N for 3.5 hr. Salts of I 21-sulfate and II with PhCH2NHCH2CH2NHCH2Ph also were prepd.
Also in the Knowledge Center
/ Apr 16, 2020
Macrocyclic lactone formulations, methods of their preparation and use of the formulations in treating pathologies secondary to ophthalmic parasites
Read more
Scientific Article
/ Jan 05, 2020
A multicentre, randomized, double鈥恗asked, parallel group, vehicle鈥恈ontrolled phase IIb study
Read more
Scientific Article
/ Jan 15, 2020
A fundamental study on strain rate sensitivity of spray dried solid dispersions
Read more
Scientific Article