Knowledge Center

Patent / Jan 01, 1976

Sulfate and phosphate 21-esters of corticosteroids

Authors:
  • Ivan Villax
Source:
US 3773803

Betametasone (I) 21-phosphate (II) was prepd. in 96.7% yield by refluxing III (R = I) in 40 ml acetone with 1.2 g H3PO4 and 5.8 ml Et3N for 3.5 hr. Salts of I 21-sulfate and II with PhCH2NHCH2CH2NHCH2Ph also were prepd.

Also in the Knowledge Center

Related Content

Filling

Fully-integrated Filling for your device needs.

Page
Read more

Analytical Support

ËÄÉ«AV has experience and capabilities to provide analytical services for Drug Substance, Drug Product and Inhalation Drug Product at all stages of development and commercial phases.

Page
Read more

Drug Substance Manufacturing

We have an exceptional range of flexible manufacturing equipment to ensure availability and suitability for our customers’ manufacturing needs.

Page
Read more