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A spray drying process with continuous preparation of spray solution
The present invention discloses a spray drying process characterized by continuous prepn. and immediate spray drying of a soln. comprising at least one active pharmaceutical ingredient and鈥/or at least one excipient, and at least one solvent.听The said active pharmaceutical ingredient(s) and solvent(s) are combined, alone or along with one or more excipients to form a first suspension.听Said suspension is continuously fed to an intensifier pump that pushes said suspension through at least one micro-鈥媟eaction chamber and鈥/or at least one micro-鈥媍hannel where the suspension's solid(s) component(s) is(are) dissolved into said solvent(s) by high energy mixing / forced contact at micro, nano and mol. level to form a soln. stream.听The said soln. stream is then immediately and continuously fed to the spray dryer through at least one atomization nozzle, drying said atomized stream to obtain solid particles and collecting said solid particles.听Single component particles or multi-鈥媍omponent particles, particulate amorphous solid dispersion and pharmaceutical compns. are also disclosed.听The present invention also discloses amorphous solid dispersions obtained by the method of the invention as well as pharmaceutical compns. contg. the same.
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