Knowledge Center
Patent / Jan 01, 1972
Polymetaphosphate complexes of .alpha.-6-deoxy-5-hydroxy tetracyclines
Source:
DE 2152476
The title Na phosphate complexes, useful as antibiotics and more sol. in water than the corresponding acid complexes, were prepd. by reaction of the tetracycline with Na hexametaphosphate or HPO3 then NaOH in an inert org. solvent, e.g., DMF, EtOH, MeOH, or CHCl3.
Also in the Knowledge Center
/ Sep 01, 2023
In vitro dissolution/permeation tools for amorphous solid dispersions bioavailability forecasting I: Experimental design for PermeaLoop
Read more
Scientific Article
/ Sep 01, 2023
In vitro dissolution/permeation tools for amorphous solid dispersions bioavailability forecasting II: Comparison and mechanistic insights
Read more
Scientific Article
Scientific Article