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Patent / Aug 18, 2016

New polymorphic forms of minocycline base and process for their preparation

Authors:
  • Zita Mendes
  • Constanca Cacela
Source:
WO 2016128760

The present invention concerns new forms of crystalline minocycline base. In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their use in pharmaceutical compositions are also provided. Form IV and form V are prepared by dissolving and/or suspending minocycline base in an organic solvent followed by crystallization.

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