Knowledge Center
Patent / Jan 01, 1957
Esters of penicillin
Source:
GB 759603
Penicillin esters are prepd. by reaction of acid halides of penicillin (I) with an alkali in an inert org. solvent. PCl3 mixed with CHCl3 is added to I suspended in CHCl3, and pyridine is added at -2.degree.. After addn. of Et2O and recrystn. from CHCl3, the HCl of the diethylaminoethyl ester of I, m. 146-8.degree., is obtained. The HI of the diethylaminoethyl ester of I, m. 168-71.degree., the Me ester of I, and the cyclohexyl ester of I can be prepd. in a similar manner.
Also in the Knowledge Center
Scientific Article
/ Jan 01, 2007
Process for the manufacture of iohexol by the alkylation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide with 1-chloro-2,3-propanediol using 2-(2-methoxyethoxy)ethanol as the reaction solvent
Read more
Scientific Article
Scientific Article