Knowledge Center
Patent / Jan 01, 1976
Esters and ethers of 16-methyl-9.alpha.-halocorticosteroids
Source:
GB 1511820
Pregnadienediones I (R = Cl, F; R1 = H, COCF3, COEt, Ac; R2 = H, OH, OAc; R3 = H, COBu) (18 compds.) were prepd. Thus, acylation of I (R = Cl, R1-R3 = H) using (F3CCO)2O followed by BuCO2H gave I (R = Cl, R1 = COCF3, R2 = H, R3 = COBu) (II). Iodination of II and subsequent acetolysis gave I (R = Cl, R1 = COCF3, R2 = OAc, R3 = COBu) which was partially deacylated to I (R = Cl, R1 = H, R2 = OAc, R3 = COBu) (III). The antiinflammatory activity of III was 4.5 times that of fluocinolone acetonide.
Also in the Knowledge Center
Scientific Article
/ Jan 01, 2007
Process for the manufacture of iohexol by the alkylation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide with 1-chloro-2,3-propanediol using 2-(2-methoxyethoxy)ethanol as the reaction solvent
Read more
Scientific Article
Scientific Article