Knowledge Center
Patent / Jan 01, 1975
Doxycycline alkali metaphosphate complexes
Source:
GB 1463726
Treatment of doxycycline (I, .alpha.-6-desoxy-5-hydroxytetracycline) with HPO3 (mole ratio I-HPO3 = 1-5:1) in an inert medium (e.g., CHCl3 or MeOH), then treating the excess HPO3 with methanolic or ethanolic NaOH or KOH gave a doxycycline alkali polyphosphate complex x I.y MPO3.z HPO3 [M = Na or K, x = 1-5, y = 1-5, z = 1-5 (y+z = 6, x .ltoreq. z], the soly. of which is such that, when taken internally, it maintains a more even and higher oxycycline concn. in blood than the known doxycycline hyclate.
Also in the Knowledge Center
/ Apr 16, 2020
Macrocyclic lactone formulations, methods of their preparation and use of the formulations in treating pathologies secondary to ophthalmic parasites
Read more
Scientific Article
/ Jan 05, 2020
A multicentre, randomized, double鈥恗asked, parallel group, vehicle鈥恈ontrolled phase IIb study
Read more
Scientific Article
/ Jan 15, 2020
A fundamental study on strain rate sensitivity of spray dried solid dispersions
Read more
Scientific Article