Knowledge Center

Patent / Jan 01, 2002

Crystallization process for the preparation of crystalline and solvent-free iohexol

Authors:
  • Guy Villax
  • Carlos Alvarez
Source:
US 6469208

Industrial process for the purifn. and removal of residual solvents from iohexol, is presented which is based on the suspension of cryst. iohexol, eventually contg. residual solvents above 100 ppm, a fluid whereit has a low soly., followed by heating, filtration, and drying. This process enables the formation of cryst. iohexol with no residual org. residual solvent above 100 ppm and with increased purity level.

Also in the Knowledge Center

Related Content

ËÄÉ«AV DMFs at FDA

List of DMFs

Page
Read more

Dry Powder Inhalation formulation development

ËÄÉ«AV has considerable inhalation experience that allows us to implement strategies including conventional carrier based, neat (drug-alone) or composite particle formulations.

Page
Read more

History of ËÄÉ«AV

ËÄÉ«AV was established in Portugal in 1959 by Ivan Villax with his wife, Diane Villax, and two other Hungarian refugees: Nicholas de Horthy and Andrew Onody, thus forming the name HOVIONE.

Page
Read more