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Patent / Apr 06, 2017

Crystalline pharmaceutical co-crystals of glycopyrronium bromide with lactose

Authors:
  • Zita Mendes
  • Tiago Fonseca
Source:
WO 2017212273 20171214

The present invention provides co-​crystals of glycopyrronium bromide with lactose.ÌýThe glycopyrronium bromide and lactose in the novel co-​crystals are present in a stoichiometric ratio of from about 1 :2 to 2: 1.ÌýThese are characterized by XRD and DSC.ÌýProcesses for prepg. the novel co-​crystals are also provided.ÌýThe co-​crystals are also disclosed for use as a medicament, in particular, for treatment of respiratory complaints, such as chronic pulmonary obstructive disease (COPD)​, bronchitis and asthma.ÌýPharmaceutical compns. comprising the co-​crystals as active ingredient are also presented.

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