Knowledge Center
Patent / Jan 01, 1973
16.beta.-Methyl-17.alpha.-hydroxypregna-1,4,9(11)-triene-3,20-dione and analogs
Source:
GB 1397267
Pregnatrienedione I was prepd. from epoxypregnanetrione II in 7 steps. Thus, II underwent ketalization with HOCH2CH2OH, KBH4 redn., dehydration, Grignard reaction with MeMgBr, and deketalization to give pregnenedione III. III was treated with Br2-HOAc and then debrominated to I.
Also in the Knowledge Center
Scientific Article
/ Jan 01, 2006
Process for the preparation of tamsulosin and intermediates thereof starting from chiral phenylethylamine and using catalytic hydrogenation as the key step
Read more
Scientific Article
/ Jan 01, 2006
Process for preparation of fluticasone analogs via esterification of a carbothioic acid
Read more
Scientific Article