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Article / Oct 23, 2016

Dry-Powder Inhalation Formulation: Balancing Performance and Manufacturability

Authors:
  • Conrad Winters
  • Eunice Costa
Source:
Pharma's Almanac, Q4 2016, 23 October 2016

There is growing demand for聽dry-powder inhalation formulations聽of drugs to treat both respiratory and systemic diseases. Composite particle technology is allowing the development of more efficient formulations, even for challenging molecules.聽Spray drying聽is an聽 enabling technology for composite particle preparation. Formulators must be aware, however, of the tradeoffs between properties that improve aerodynamic performance in the lung but negatively impact聽 process yields or throughputs.