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PLGA-based microspheres have become one of the most attractive drug delivery platforms for controlled release. These offer a range of unique advantages, including protection of the encapsulated drug, possibility to tune the drug release profile and minimal systemic toxicity due to the inherent biodegradable and biocompatible properties of PLGA. Controlled release platforms are particularly attractive for patients who are not capable of following a treatment plan and for the delivery of drugs with a narrow therapeutic 鈥渨indow鈥�, such as highly potent drugs.