Knowledge Center

Patent / Jan 01, 2008

Process for the preparation of biphosphonic acids and salts thereof

Authors:
  • Joana Baptista
Source:
WO 2008056129

A process for the prepn. of biphosphonic acids, (HO)2P(O)C(R1)(OH)P(O)(OH)2 (R1 = alkyl, arylalkyl, arom., heteroarom.), and pharmaceutical acceptable salts thereof, comprises reacting a carboxylic acid with phosphorous trichloride and phosphorous acid the presence of aprotic polar solvent. Thus, reaction of 3-pyridylacetic acid with H3PO3 N,N'-dimethylethyleneurea at 40-50 followed by treatment with PCl3 and adjusting pH to 8-9 via treatment with NaOH gave 60% risedronic acid sodium salt.

Also in the Knowledge Center

Related Content

ASD-HIPROS

ASD-HIPROS, ËÄÉ«AV’s Intelligent Proprietary Screening, is the most advanced and accurate tool to identify Amorphous Solid Dispersion formulations by Spray Drying with maximum performance and stability.

Page
Read more

Customers

Full transparency for your project anywhere at any time.

Page
Read more

60 Years

In 2019, ËÄÉ«AV celebrates its 60th Anniversary.

Page
Read more