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Patent / Jan 01, 2011

Method for monofluoromethylation of organic substrates to prepare biologically active organic compounds

Authors:
  • Emilia Leitao
Source:
WO 2011151624

A process for the prepn. of monofluoromethylated org. biol. active compds. using monofluoromethylated reagents was disclosed. Thus, fluticasone propionate and fluticasone furoate I [R = CH2Me, 2-furanyl, resp.] were prepd. using S-monofluoromethyl-S-phenyl-2,3,4,5-tetramethylphenylsulfonium tetrafluoroborate as monofluoromethylating reagent instead of bromofluoromethane.

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