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During formulation development, efficiently integrating ¾±²ÔÌý±¹¾±³Ù°ù´Ç dissolution testing can significantly improve one's ability to estimate ¾±²ÔÌý±¹¾±±¹´Ç performance and aide in the selection of premier drug candidates. The concept of ¾±²ÔÌý±¹¾±³Ù°ù´Ç–¾±²ÔÌý±¹¾±±¹´Ç relationship/correlation has garnered significant attention from pharmaceutical scientists to predict expected bioavailability characteristics for drug substances and products. The present work illustrates a comparative evaluation of ¾±²ÔÌý±¹¾±³Ù°ù´Ç tests to access crystalline carbamazepine and various types of amorphous and crystalline dispersions of carbamazepine and Eudragit® L100 produced by spray drying, including a membrane-permeation dissolution methodology and nonsink dissolution. To establish the best model, parameters such as pH, membrane constitution, and dissolution media composition were investigated. The ¾±²ÔÌý±¹¾±³Ù°ù´Ç results were compared against ¾±²ÔÌý±¹¾±±¹´Çmice pharmacokinetic studies and qualitatively, the membrane-permeation dissolution methodology correlated well with ¾±²ÔÌý±¹¾±±¹´Ç. Various correlations were performed in order to evaluate the optimal model for characterizing the relationship. Results exhibited a coefficient of determination (R2) values of 0.90 and 1.00, depicting a linear relationship of the data in comparison. Therefore, for the current formulation system (drug/polymer/technique), membrane-permeation dissolution can guide formulation development and potentially reduce the number of animal and clinical pharmacokinetic studies required.